ACE gene polymorphism and renal scarring in primary vesicoureteric reflux

The objective of this study was to investigate whether mutations of the renin-angiotensin system genes are involved in primary vesicoureteric reflux (VUR) and VUR-associated renal scarring. The M235T polymorphism of the angiotensinogen ( ATG) gene, the I/D polymorphism of the angiotensin converting...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2002-12, Vol.17 (12), p.1027-1031
Main Authors: HASZON, Ibolya, FRIEDMAN, Aaron L, PAPP, Ferenc, BERECZKI, Csaba, BAJI, Sandor, BODROGI, Tibor, KAROLY, Eva, ENDREFFY, Emöke, TURI, Sandor
Format: Article
Language:English
Subjects:
Alleles
Angiotensinogen - genetics
Biological and medical sciences
Child
Female
Genetic Markers
Genotype
Humans
Kidney - pathology
Male
Medical sciences
Nephrology. Urinary tract diseases
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic - genetics
Receptor, Angiotensin, Type 1
Receptors, Angiotensin - genetics
Renin-Angiotensin System - genetics
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
Vesico-Ureteral Reflux - genetics
Vesico-Ureteral Reflux - pathology
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Summary:The objective of this study was to investigate whether mutations of the renin-angiotensin system genes are involved in primary vesicoureteric reflux (VUR) and VUR-associated renal scarring. The M235T polymorphism of the angiotensinogen ( ATG) gene, the I/D polymorphism of the angiotensin converting enzyme ( ACE) gene, and the A1166C polymorphism of the angiotensin II type 1 receptor ( AT1) gene were identified in 77 patients with primary VUR (aged 6.9+/-3.2 years, mean+/-SD) and 80 healthy controls (aged 33+/-7 years). Thirty-eight of the 77 VUR patients had low-grade VUR (grade I-III) and 39 had high-grade VUR (grade IV and V). Renal scarring was found in 43 VUR patients, while 34 patients had normal kidneys on dimercaptosuccinic acid scan. The ACE gene polymorphism was determined by polymerase chain reaction and the ATG and AT1 gene polymorphisms were determined by single-step LightCycler technology. We found significant over-representation of the DD genotype in patients with renal scarring (44 %) compared with normal controls (23%, P
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-002-0968-1