Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide

5-Methyl-1,2,4-triazolo[1,5- a ]pyrimidin-7(4 H )-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3 H -1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl 2 in supercritical carbo...

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Bibliographic Details
Published in:Russian journal of general chemistry 2019, Vol.89 (1), p.151-152
Main Authors: Baklykov, A. V., Rusinov, G. L., Rusinov, V. L., Charushin, V. N., Kopchuk, D. S., Zyryanov, G. V., Artem’ev, G. A.
Format: Article
Language:English
Subjects:
Antiviral agents
Carbon dioxide
Catalysis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Condensates
Letters to the Editor
Production processes
Reaction time
Synthesis
Zinc chloride
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Summary:5-Methyl-1,2,4-triazolo[1,5- a ]pyrimidin-7(4 H )-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3 H -1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl 2 in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219010274