Lanthanum doped fern-like CuO nanoleaves/MWCNTs modified glassy carbon electrode for simultaneous determination of tramadol and acetaminophen

• Published in: Sensors and actuators. B, Chemical Chemical, 2019-04, Vol.285, p.562-570
• Main Authors: Foroughi, Mohammad Mehdi, Jahani, Shohreh, Hassani Nadiki, Hadi
• Format: Article
• Language: English
• Subjects: Acetaminophen; Analgesics; Carbon; Electrodes; Electrons; Glassy carbon; Lanthanum; Lanthanum doped fern-like CuO nanoleaves; Modified electrode; Morphology; Multi wall carbon nanotubes; Nanocomposites; Oxidation; Sensitivity; Sensors; Tramadol; Voltammetry; X ray photoelectron spectroscopy
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2019.01.069

•Lanthanum doped fern like CuO nanoleaves were characterized by FT-IR, EDX, XRD, XPS, SEM and TEM.•La3+-CuO/MWCNT was used as the modifier.•This modified electrode was used for the simultaneous determination of tramadol and acetaminophen.•Modification improved the sensitivity and detection limit of the method. An innovative and adept single-stage approach was created to synthesis lanthanum doped fern like CuO nanoleaves (La3+-CuO fern-like nanoleaves). The morphology and structure of fern like La3+-CuO nanoleaves are characterized by using the FT-IR, EDX, SEM, XPS and TEM techniques. Drop casting fern-like La3+-CuO nanoleaves suspension on MWCNTs/GC was used to fabricate the La3+-CuO/MWCNTs nanocomposites modified glassy carbon (GC) electrode. For electrochemical behavioral assessment of tramadol, differential pulse voltammetric analysis (DPV) and cyclic voltammetry (CV) was implemented and the oxidation performance on MWCNTs/GC, La3+-CuO/MWCNTs/GC and bare GC was compared. The obtained results indicate that amalgamation of fern-like La3+-CuO nanoleaves and multiwall carbon nanotubes will entail a significant improvement of sensor sensitivity. A limit detection of 0.014 μM within a linear range of 0.5–900.0 μM was determined for obtaining the quantitative tramadol detection. Moreover, this sensor proved favorable to simultaneously determine tramadol and acetaminophen. Additionally, great sensitivity and stability was shown by the fabricated sensor which will be beneficial for tramadol and acetaminophen clinical assay.