A thermoresponsive nanocarrier for mitochondria-targeted drug delivery

Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer c...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (28), p.451-454
Main Authors: Wang, Dongqing, Huang, Hui, Zhou, Mengxue, Lu, Huiru, Chen, Jun, Chang, Young-Tae, Gao, Jimin, Chai, Zhifang, Hu, Yi
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacology
Cancer
Cell Line
Cell Proliferation - drug effects
Cell Survival - drug effects
Dose-Response Relationship, Drug
Drug Carriers - chemistry
Drug delivery systems
Drug Screening Assays, Antitumor
High temperature
Humans
Mice
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Nanoparticles - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Paclitaxel - administration & dosage
Paclitaxel - pharmacology
Structure-Activity Relationship
Temperature
Temperature dependence
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Summary:Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy. A thermoresponsive nanocarrier was developed for mitochondria-targeted drug delivery.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc00603f