MCQs for "Treatment in resectable non-metastatic adenocarcinoma of stomach: Changing paradigms"

The advantages of neoadjuvant chemotherapy (NaCT) in nonmetastatic gastric cancer include all except Tumor downstagingSurgery can be avoided in some casesPreoperative chemotherapy (CT) is better tolerated than postoperative CTEradication of tumor micrometastases As per current available evidence, ad...

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Bibliographic Details
Published in:Indian journal of cancer 2019-01, Vol.56 (1), p.81-82
Main Authors: Darling, H, Jayalakshmi, Senguttuvan, Jaiswal, Pradeep
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adjuvant chemotherapy
Advantages
Biopsy
Cancer metastasis
Cancer research
Cancer therapies
Cancer treatment
Care and treatment
Chemotherapy
Dissection
Gastric cancer
Lymphatic system
Medical prognosis
Neoadjuvant therapy
Radiation therapy
Stomach cancer
Surgery
Tumors
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Summary:The advantages of neoadjuvant chemotherapy (NaCT) in nonmetastatic gastric cancer include all except Tumor downstagingSurgery can be avoided in some casesPreoperative chemotherapy (CT) is better tolerated than postoperative CTEradication of tumor micrometastases As per current available evidence, adjuvant chemoradiotherapy (CRT) is most appropriate in Patients with residual disease at surgery after NaCTPatients who have not received NaCTPatients with node positive disease at surgeryPatients with D1 resection The conclusions from phase 3 study comparing NaCT followed by surgery followed by randomization to CT vs CRT are following except NaCT does not improve survivalThere is no progression-free survival (PFS) benefit of adding radiotherapy (RT)Completion of postoperative treatment was a challengeOS (overall survival) was numerically more in the CT arm Laurens intestinal type of gastric adenocarcinoma with a more common distal location of tumors is common in HispanicsAfrican AmericansAsiansPacific islanders The Japanese classification of gastric carcinoma as D1, D2, and D3 is based on Stage of gastric cancerType of anastamosis after surgical resectionExtent of nodal dissection in surgery resectionExtent of mucosal serosal involvement The Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) and SWOG---intergroup trials---two randomised controlled trials were practice changing in demonstrating a survival advantage in gastric cancer with Radical surgery aloneAddition of radiotherapyIntraoperative radiotherapyPerioperative chemotherapy/adjuvant chemoradiotherapy The contentious issue of validity of pathological staging and biological response of the tumor to preoperative chemotherapy is being evaluated by which of the following ongoing trails MAGIC and SWOG trailsARTIST II and TOPGEAR trialsTo Ga and AVAGAST trialsCLASSIC and CRITICS trials Incidence of lymph nodal metastasis in early gastric cancers limited to mucosa is 3%10%20%50% D1+ nodal dissection as described in Chemoradiotherapy after Induction Chemotherapy in Cancer of the Stomach (CRITICS) trial involves Dissection of lymph node stations 1–12Dissection of lymph node station 1–10Dissection of lymph node stations 1–9 and 11Dissection of lymph node station 1–8 The drug regimen used in landmark MAGIC trial was Epirubicin, Cisplatin, and 5FU (ECF infusional)Capecitabine, OxaliplatinEpirubicin, Cisplatin, and 5FU (ECF bolus)Cisplatin, capecitabine. Surgery is the mainstay of treatment in
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.IJC_210_19