Eptifibatide-induced thrombocytopenia and thrombosis

Glycoprotein (GP) IIb/IIIa inhibitors have been shown to reduce morbidity and mortality in patients with acute coronary syndromes undergoing percutaneous coronary interventions (PCI). With their widespread use, there is a growing body of literature describing adverse outcomes, including severe throm...

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Bibliographic Details
Published in:Journal of thrombosis and thrombolysis 2006-10, Vol.22 (2), p.151-154
Main Authors: Epelman, Slava, Nair, Deepu, Downey, Ross, Militello, Mike, Askari, Arman T
Format: Article
Language:English
Subjects:
Aged
Humans
Male
Myocardial Infarction - drug therapy
Peptides - adverse effects
Peptides - therapeutic use
Platelet Aggregation Inhibitors - adverse effects
Platelet Aggregation Inhibitors - therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors
Thrombocytopenia - chemically induced
Venous Thrombosis - chemically induced
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Summary:Glycoprotein (GP) IIb/IIIa inhibitors have been shown to reduce morbidity and mortality in patients with acute coronary syndromes undergoing percutaneous coronary interventions (PCI). With their widespread use, there is a growing body of literature describing adverse outcomes, including severe thrombocytopenia. Here we report a case of a 75-year-old man who presented with an ST-elevation myocardial infarction, underwent primary PCI and stenting, and subsequently developed profound thrombocytopenia and thrombosis after eptifibatide administration. This report adds to the literature regarding eptifibatide-induced thrombocytopenia and also raises the possibility of a new syndrome of eptifibatide-induced thrombosis. A case is made to examine available databases for thrombosis after administration of eptifibatide and other GPIIb/IIIa inhibitors.
ISSN:0929-5305
1573-742X
DOI:10.1007/s11239-006-8785-1