A case of pan‐resistant Burkholderia cepacia complex bacteremic pneumonia, after lung transplantation treated with a targeted combination therapy

We describe a case of one patient with cystic fibrosis who developed a pan‐resistant Burkholderia cepacia complex rapidly progressive bacteraemic pneunonia, following bilateral lung transplantation. The patient was treated with a targeted combination antibiotic therapy (meropenem plus ceftazidime/av...

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Bibliographic Details
Published in:Transplant infectious disease 2019-04, Vol.21 (2), p.e13034-n/a
Main Authors: Cantón‐Bulnes, María Luisa, Hurtado Martínez, Ángela, López‐Cerero, Lorena, Arenzana Seisdedos, Ángel, Merino‐Bohorquez, Vicente, Garnacho‐Montero, José
Format: Article
Language:English
Subjects:
Antibiotics
bacteraemic pneumonia
Burkholderia cepacia
Ceftazidime
Cystic fibrosis
Lung transplantation
Meropenem
pan‐resistant Burkholderia Cepacia complex
Sodium
Therapy
Transplantation
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Summary:We describe a case of one patient with cystic fibrosis who developed a pan‐resistant Burkholderia cepacia complex rapidly progressive bacteraemic pneunonia, following bilateral lung transplantation. The patient was treated with a targeted combination antibiotic therapy (meropenem plus ceftazidime/avibactam plus high doses of nebulized colistimethate sodium). Evolution of the disease was complicated by multiple organ system dysfunction. Finally, clinical improvement and microbiological cure was achieved.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.13034