Cancer Diagnostics: Visual Quantitative Detection of Circulating Tumor Cells with Single‐Cell Sensitivity Using a Portable Microfluidic Device (Small 14/2019)

In article number 1804890, Zhi Zhu and co‐workers realize visual quantitative detection of circulating tumor cells (CTCs) using a portable volumetric bar chart chip (V‐Chip) with singlecell sensitivity. The target CTCs are labeled with aptamer conjugated nanoparticles that can catalyze the generatio...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2019-04, Vol.15 (14), p.n/a
Main Authors: Abate, Mahlet Fasil, Jia, Shasha, Ahmed, Metages Gashaw, Li, Xingrui, Lin, Li, Chen, Xiaoqian, Zhu, Zhi, Yang, Chaoyong
Format: Article
Language:English
Subjects:
circulating tumor cells
Microfluidic devices
microfluidics
Nanoparticles
Nanotechnology
portable device
Portable equipment
Sensitivity
single‐cell sensitivity
Tumors
visual quantification
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Summary:In article number 1804890, Zhi Zhu and co‐workers realize visual quantitative detection of circulating tumor cells (CTCs) using a portable volumetric bar chart chip (V‐Chip) with singlecell sensitivity. The target CTCs are labeled with aptamer conjugated nanoparticles that can catalyze the generation of oxygen for the movement of an ink bar in the V‐Chip. The CTC number is quantified by the distance of the ink bar visually. This portable detection method shows great potential for quantification of rare cells with single‐cell sensitivity for various applications.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201970075