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A new facile method for the synthesis of 3-imidazolylpropionic acid N-oxides

A facile and efficient method for the preparation of 3-imidazolylpropionic acid N -oxides has been developed. It involves condensation of 2-unsubstituted imidazole N -oxide with an aldehyde and Meldrum's acid followed by hydrolysis and decarboxylation of the corresponding adduct. This method to...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-02, Vol.55 (2), p.147-155
Main Authors: Kutasevich, Anton V., Perevalov, Valery P., Mityanov, Vitaly S., Lichitsky, Boris V., Komogortsev, Andrey N., Krayushkin, Mikhail M., Koldaeva, Tatyana Yu, Miroshnikov, Vladimir S.
Format: Article
Language:English
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Summary:A facile and efficient method for the preparation of 3-imidazolylpropionic acid N -oxides has been developed. It involves condensation of 2-unsubstituted imidazole N -oxide with an aldehyde and Meldrum's acid followed by hydrolysis and decarboxylation of the corresponding adduct. This method tolerates a broad variation in the structure of starting aldehydes as well as N -oxides.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02431-7