Morphometric and molecular study of corpus cavernosum of the rat after longterm high-fat diet intake

Erectile dysfunction (ED) is considered equivalent to endothelial dysfunction and thus an early manifestation of atherosclerosis and cardiovascular disease (CVD). Atherosclerosis that is frequently provoked by regular consumption of high-fat diet (HFD) has been recently recognized as a chronic infla...

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Bibliographic Details
Published in:Microscopy and microanalysis 2009-07, Vol.15 (S3), p.21-22
Main Authors: Tomada, I., Tomada, N., Almeida, H., Vendeira, P., Neves, D.
Format: Article
Language:English
Subjects:
Adipocytes
Animals
Atherosclerosis
Cardiovascular diseases
Diet
Endothelium
Life Sciences
Nutrition research
Smooth muscle
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Summary:Erectile dysfunction (ED) is considered equivalent to endothelial dysfunction and thus an early manifestation of atherosclerosis and cardiovascular disease (CVD). Atherosclerosis that is frequently provoked by regular consumption of high-fat diet (HFD) has been recently recognized as a chronic inflammation condition associated to vessel lipid deposition and vascular smooth cells proliferation that together impair endothelium-dependent relaxation of corpus cavernosum (CC) smooth muscle. It is also well established that HFD regular intake by its own induces endothelial dysfunction. The main objective of this study was to evaluate effects of HFD continuous intake on atherosclerosis progression of CC vessels of the rat. Due to their intervention on atherosclerosisrelated vascular remodelling pathways, angiopoietins (Ang1, Ang2) expression in erectile tissue of this rat experimental model was characterized.
ISSN:1431-9276
1435-8115
DOI:10.1017/S1431927609990560