Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.

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Bibliographic Details
Published in:Russian journal of general chemistry 2019-02, Vol.89 (2), p.357-363
Main Authors: Ahmed, A. H., Ebead, A., Afifi, H., Abdel-Rahman, A. A.-H.
Format: Article
Language:English
Subjects:
Alkylation
Anticancer properties
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydantoin
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Description
Summary:New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219020294