Methyl Trifluoropyruvate Pyrazin-2-ylimine in Cyclocondensation and Cycloaddition Reactions

The transformations of methyl trifluoropyruvate pyrazin-2-ylimine in the cyclocondensation reactions with 2-aminothiazoline, amidines, aminocrotonitrile and aza-Diels—Alder reactions with cyanamines, leading to five- and six-membered trifluoromethyl-containing heterocycles, were studied. The possibi...

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Bibliographic Details
Published in:Russian journal of general chemistry 2019-02, Vol.89 (2), p.364-367
Main Authors: Sokolov, V. B., Aksinenko, A. Yu
Format: Article
Language:English
Subjects:
Alkynes
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
Diels-Alder reaction
Letters to the Editor
Lipid peroxidation
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Summary:The transformations of methyl trifluoropyruvate pyrazin-2-ylimine in the cyclocondensation reactions with 2-aminothiazoline, amidines, aminocrotonitrile and aza-Diels—Alder reactions with cyanamines, leading to five- and six-membered trifluoromethyl-containing heterocycles, were studied. The possibility of using 4-(pyrazin-2-ylamino)-1-(prop-2-yn-1-yl)-4-(trifluoromethyl)-1 H -imidazol-5(4 H )-one, the product of methyl trifluoropyruvate pyrazin-2-ylimine cyclocondensation, for modification of phenothiazine by copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition was shown.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219020300