Cell Mechanosensing

Mechanical forces are known to play important roles in determining cellular functions and behaviours such as growth, migration, wound healing and tissue regeneration, to name a few. It is quite intriguing how cells sense the mechanical forces and properties of the surrounding matrix in which the cel...

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Bibliographic Details
Published in:Resonance 2019-01, Vol.24 (3), p.289-296
Main Author: De, Rumi
Format: Article
Language:English
Subjects:
Cell adhesion & migration
Cellular biology
Science education
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Summary:Mechanical forces are known to play important roles in determining cellular functions and behaviours such as growth, migration, wound healing and tissue regeneration, to name a few. It is quite intriguing how cells sense the mechanical forces and properties of the surrounding matrix in which the cells float or rest. The cells are known to build numerous ‘adhesion contacts’ at the cell-matrix interface to probe the surroundings. These adhesion contacts, known as ‘focal adhesions’ are highly dynamic and strongly force sensitive. In this article, we discuss about the focal adhesions which act as mechanosensors and, in turn, regulate cellular activity.
ISSN:0971-8044
0973-712X
DOI:10.1007/s12045-019-0780-x