Response to Flumazenil in Women With Premenstrual Dysphoric Disorder

OBJECTIVE: The authors sought to determine whether the administration of flumazenil would induce marked panic symptoms in women suffering from premenstrual dysphoric disorder.METHOD: Ten women with premenstrual dysphoric disorder and 11 comparison subjects were injected with flumazenil or placebo in...

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Bibliographic Details
Published in:The American journal of psychiatry 2000-05, Vol.157 (5), p.821-823
Main Authors: Le Mellédo, Jean-Michel, Van Driel, Michelle, Coupland, Nicholas John, Lott, Paula, Jhangri, Gian S.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Cross-Over Studies
Double-Blind Method
Drug therapy
Female
Female genital diseases
Flumazenil - pharmacology
GABA Modulators - pharmacology
Gynecology. Andrology. Obstetrics
Humans
Luteal Phase - physiology
Luteal Phase - psychology
Medical sciences
Menstruation
Non tumoral diseases
Panic attacks
Panic disorder
Panic Disorder - chemically induced
Panic Disorder - diagnosis
Panic Disorder - psychology
Premenstrual Syndrome - diagnosis
Premenstrual Syndrome - physiopathology
Premenstrual Syndrome - psychology
Psychiatric Status Rating Scales - statistics & numerical data
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, GABA - drug effects
Receptors, GABA - physiology
Severity of Illness Index
Women
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Summary:OBJECTIVE: The authors sought to determine whether the administration of flumazenil would induce marked panic symptoms in women suffering from premenstrual dysphoric disorder.METHOD: Ten women with premenstrual dysphoric disorder and 11 comparison subjects were injected with flumazenil or placebo in a double-blind, randomized, balanced crossover design in a single session in the luteal phase of their menstrual cycles.RESULTS: Flumazenil induced a much greater panic response in the women with premenstrual dysphoric disorder than in the comparison subjects.CONCLUSIONS: These preliminary results are consistent with a dysregulation of the g-aminobutyric acid A benzodiazepine receptor complex during the premenstruum of women suffering from premenstrual dysphoric disorder.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.157.5.821