Neural Correlates of Traumatic Memories in Posttraumatic Stress Disorder: A Functional MRI Investigation

OBJECTIVE: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. METHOD: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magne...

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Bibliographic Details
Published in:The American journal of psychiatry 2001-11, Vol.158 (11), p.1920-1922
Main Authors: Lanius, Ruth A., Williamson, Peter C., Densmore, Maria, Boksman, Kristine, Gupta, Madhulika A., Neufeld, R.W., Gati, Joseph S., Menon, Ravi S.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Brain
Brain - anatomy & histology
Brain - physiopathology
Comorbidity
Depressive Disorder, Major - epidemiology
Dysthymic Disorder - epidemiology
Female
Heart Rate - physiology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Memory
NMR
Nuclear magnetic resonance
Panic Disorder - epidemiology
Post traumatic stress disorder
Prevalence
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Stress Disorders, Post-Traumatic - epidemiology
Stress Disorders, Post-Traumatic - physiopathology
Substance-Related Disorders - epidemiology
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Summary:OBJECTIVE: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. METHOD: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength. RESULTS: PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10 11) than did the comparison subjects. CONCLUSIONS: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.158.11.1920