A cucurbituril/polysaccharide/carbazole ternary supramolecular assembly for targeted cell imaging

A carbazole derivative ( G ) was synthesized as a photosensitizer to complex with cucurbit[8]uril, resulting in a nanocube with emission at 662 nm for lysosome cell imaging. Furthermore, the alkyl chain on G was included by α-cyclodextrine-modified hyaluronic acid for further assembly, affording a s...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (3), p.4343-4346
Main Authors: Wu, Xuan, Chen, Yong, Yu, Qilin, Li, Feng-Qing, Liu, Yu
Format: Article
Language:English
Subjects:
Assembly
Carbazoles
Fluorescence
Hyaluronic acid
Polysaccharides
Zeta potential
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Summary:A carbazole derivative ( G ) was synthesized as a photosensitizer to complex with cucurbit[8]uril, resulting in a nanocube with emission at 662 nm for lysosome cell imaging. Furthermore, the alkyl chain on G was included by α-cyclodextrine-modified hyaluronic acid for further assembly, affording a system targeted to cancer cells. A ternary supramolecular assembly with near-infrared lysosome imaging and targeted photodynamic therapy properties was successfully orthogonally constructed in a two-step assembly manner.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc01601e