Small-fiber neuropathy definition, diagnosis, and treatment

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic fa...

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Bibliographic Details
Published in:Neurological sciences 2019-07, Vol.40 (7), p.1343-1350
Main Authors: Basantsova, Natalia Y., Starshinova, Anna A., Dori, Amir, Zinchenko, Yulia S., Yablonskiy, Piotr K., Shoenfeld, Yehuda
Format: Article
Language:English
Subjects:
Anxiety
Autoimmune diseases
Autonomic nervous system
Biopsy
Celiac disease
Diabetes
Diagnosis
Electromyography
Etiology
Fibers
Genetic factors
Higher education
Humans
Laboratories
Medicine
Medicine & Public Health
Metabolism
Nerve conduction
Neurology
Neuropathy
Neuroradiology
Neurosciences
Neurosurgery
Pain
Peripheral Nervous System Diseases - diagnosis
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - genetics
Peripheral Nervous System Diseases - therapy
Psychiatry
Restless legs syndrome
Review Article
Sarcoidosis
Skin
State budgets
Tumor necrosis factor-TNF
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Summary:In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-019-03871-x