A comprehensive analysis of WGCNA and serum metabolomics manifests the lung cancer‐associated disordered glucose metabolism

Lung cancer is a worldwide disease and highly heterogeneous at a molecular level. In this study, we both performed the pathway enrichment analysis and the transcriptome‐based weighted gene coexpression network analysis (WGCNA) so as to find the critical pathways involved in lung cancer. Our analysis...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-06, Vol.120 (6), p.10855-10863
Main Authors: Ding, Mingchao, Li, Fang, Wang, Bin, Chi, Guoqing, Liu, Hao
Format: Article
Language:English
Subjects:
Cancer
Carcinogenesis
Carcinogens
Enrichment
Gene expression
Genes
Glucose
Glucose metabolism
Glycolysis
Lung cancer
Metabolism
Metabolomics
Modules
Network analysis
Therapeutic applications
Viability
weighted gene coexpression network analysis
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Summary:Lung cancer is a worldwide disease and highly heterogeneous at a molecular level. In this study, we both performed the pathway enrichment analysis and the transcriptome‐based weighted gene coexpression network analysis (WGCNA) so as to find the critical pathways involved in lung cancer. Our analysis results indicated that genes in viability modules (0 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.28377