The Inhibition of Ethanol Extract of Phaleria macrocarpa Stem Bark on iNOS Expression of HCT116 Colorectal Cancer Cell Line

To determine the effect of ethanol extract from Phaleria macrocarpa stem bark on the expression of inducible Nitric Oxide Synthase (iNOS) in colorectal cancer cell line HCT116 and determined chemical substance on the extract. [4] Other study stated that iNOS is also one of the key factor in the form...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2019-03, Vol.11 (3), p.892-895
Main Authors: Harmen, Fadhilah, Hanifah, Ratu Shafira, Novitarani, Nadia Aida, Tedjo, Aryo, Azizah, Norma Nur, Putrianingsih, Rista, Fachri, Wilzar, Kusmardi, Kusmardi
Format: Article
Language:English
Subjects:
Colorectal cancer
Conflicts of interest
Ethanol
Flavonoids
Genetic disorders
Nitric oxide
Polyps
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Summary:To determine the effect of ethanol extract from Phaleria macrocarpa stem bark on the expression of inducible Nitric Oxide Synthase (iNOS) in colorectal cancer cell line HCT116 and determined chemical substance on the extract. [4] Other study stated that iNOS is also one of the key factor in the formation of colorectal cancer caused by mutation of adenomatous polyposis coli (APC) gene, believed to be underlying mechanism of sporadic colorectal cancer. Previous studies shows that treatment of S,S'-1,4-phenylenebis(1,2ethanediyl)bisisothiourea (PBIT) dan N6iminoethyl-lysine tetrazoleamide (NILT), an iNOS inhibitor, is effective in inhibiting the formation of colonic aberrant crypt foci found in colon cancer in in vivo setting. [...]the molecular mechanism of this extract wasn't assessed on this study. [...]research on exact molecular mechanism and biosafety of this extract in the future are still needed.
ISSN:0975-1459