Cell death induced by photodynamic therapy with the conjugate of gold nanoparticles-PpIX in HeLa cell line

Photodynamic therapy (PDT) is a non-conventional cancer treatment that consists in the administration of a photosensitizer (Ps) activated by light. The conjugate of protoporphyrin IX-gold nanoparticle used as Ps has showed an enhanced effect on cervical cancer cells treated with PDT. The aim of this...

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Bibliographic Details
Main Authors: Juárez, Alfonso Antonio Sequeda, Alvarado, Elizabeth Maldonado, Gallegos, Eva Ramón
Format: Conference Proceeding
Language:English
Subjects:
Apoptosis
Cancer
Cancer therapies
Cell death
Cervical cancer
Conjugates
Gold
Irradiation
Nanoparticles
Photodynamic therapy
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Summary:Photodynamic therapy (PDT) is a non-conventional cancer treatment that consists in the administration of a photosensitizer (Ps) activated by light. The conjugate of protoporphyrin IX-gold nanoparticle used as Ps has showed an enhanced effect on cervical cancer cells treated with PDT. The aim of this work was to determinate the mechanisms involved in cell death induced in HeLa by this conjugate. Cervical cancer cell line HeLa was culture, exposed to NpAu-PpIX conjugate and irradiated to 630 nm. Results showed that the conjugated induce apoptosis since first hour after irradiation. Due to the effectiveness of the PDT this could be an alternative treatment for cancers that develop resistance to conventional treatments.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5095911