Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications

Thiazolidinone is a biologically important five‐membered heterocyclic ring having almost all types of biological activities. This review covers various types of thiazolidinones, such as 2‐thiazolidinones, 4‐thiazolidinones, 5‐thiazolidinones, 2‐thioxo‐4‐thiazolidinones, and thiazolidiene‐2,4‐dione....

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2019-04, Vol.56 (4), p.1239-1253
Main Authors: Nirwan, Sonam, Chahal, Varun, Kakkar, Rita
Format: Article
Language:English
Subjects:
Antioxidants
Binders
Chemical reactions
Chemical synthesis
Cystic fibrosis
Derivatives
Diketones
Organic chemistry
Physical properties
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Summary:Thiazolidinone is a biologically important five‐membered heterocyclic ring having almost all types of biological activities. This review covers various types of thiazolidinones, such as 2‐thiazolidinones, 4‐thiazolidinones, 5‐thiazolidinones, 2‐thioxo‐4‐thiazolidinones, and thiazolidiene‐2,4‐dione. The literature related to the physical properties, chemical reactions, and synthesis for these derivatives has been included. Recent advances in the biological activities reported for 4‐thiazolidinone derivatives, such as peroxisome proliferator‐activated receptor γ binders, follicle‐stimulating hormone agonists, cystic fibrosis transmembrane conductance regulator inhibitors, and antioxidants, have been covered in this review. Thus, this study may help in further optimizing these thiazolidinone derivatives as more effective drug agents.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3514