Frontispiece: A Novel Cathode Material for Cathodic Dehalogenation of 1,1-Dibromo Cyclopropane Derivatives

Pharmaceutical Electrochemistry. The electrochemical dehalogenation represents a powerful and sustainable tool for the synthesis of pharmaceutically relevant cyclopropane building blocks in excellent yield. The key to the conversion is the leaded bronze cathode instead of traditional lead. This nove...

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Bibliographic Details
Published in:Chemistry : a European journal 2015-09, Vol.21 (40), p.n/a
Main Authors: Gütz, Christoph, Selt, Maximilian, Bänziger, Markus, Bucher, Christoph, Römelt, Christina, Hecken, Nadine, Gallou, Fabrice, Galvão, Tomás R., Waldvogel, Siegfried R.
Format: Article
Language:English
Subjects:
Cathodes
Chemistry
Contamination
Corrosion products
Cyclopropane
cyclopropanes
Dehalogenation
electrochemical reduction
Electrochemistry
Electrode materials
Electrolysis
Heavy metals
leaded bronze
Leaded bronzes
Plasma
sustainable chemistry
Workers
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Summary:Pharmaceutical Electrochemistry. The electrochemical dehalogenation represents a powerful and sustainable tool for the synthesis of pharmaceutically relevant cyclopropane building blocks in excellent yield. The key to the conversion is the leaded bronze cathode instead of traditional lead. This novel cathode material is less prone to corrosion and provides highly pure product. Thereby, contamination by heavy metal traces is tremendously reduced. Furthermore, by slightly switching the electrolysis conditions, selective mono‐ or twofold dehalogenation is achieved. For more details, see the Communication by S. R. Waldvogel and co‐workers on page 13878 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201584061