High‐Throughput Drug Screening: A Microfabricated Sandwiching Assay for Nanoliter and High‐Throughput Biomarker Screening (Small 15/2019)

In article number 1900300, Junmin Lee, Ali Khademhosseini, and co‐workers develop a nanoliter and high‐throughput drug screening platform based on the combination of microwell arrays as a cell culture substrate, and micropillar arrays for drug delivery and biomolecular detection in response to drugs...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2019-04, Vol.15 (15), p.n/a
Main Authors: Bandaru, Praveen, Chu, Dafeng, Sun, Wujin, Lasli, Soufian, Zhao, Chuanzhen, Hou, Shuang, Zhang, Shiming, Ni, Jiahua, Cefaloni, Giorgia, Ahadian, Samad, Dokmeci, Mehmet Remzi, Sengupta, Shiladitya, Lee, Junmin, Khademhosseini, Ali
Format: Article
Language:English
Subjects:
Biomarkers
Drug delivery systems
drug screening
high‐throughput screening
micropillars
microwells
Nanotechnology
Screening
Substrates
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Summary:In article number 1900300, Junmin Lee, Ali Khademhosseini, and co‐workers develop a nanoliter and high‐throughput drug screening platform based on the combination of microwell arrays as a cell culture substrate, and micropillar arrays for drug delivery and biomolecular detection in response to drugs. The developed platform requires only a small amount of sample volume from a few cells and demonstrates increasing control and throughput while allowing direct and real‐time on‐chip measurements. It is expected to aid in improving drug screening on patient biopsies from solid tumors to realize personalized cancer therapy.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201970078