Effect of lead on the calcium transport in human erythrocyte

In this paper we study the calcium uptake in the erythrocyte, a non-excitable cell. This uptake is performed through a passive transport system with two kinetic components (Michaelis-Menten and Hill). The uptake of calcium seems to be driven by voltage through its electrophoretical effect. Lead is c...

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Bibliographic Details
Published in:Human & experimental toxicology 1999-03, Vol.18 (3), p.146-153
Main Authors: Calderón-Salinas, J.V., Quintanar-Escorza, M.A., Hernández-Luna, C.E., González-Martínez, M.T.
Format: Article
Language:English
Subjects:
Biochemistry
Hemoglobin
Homeostasis
Intoxication
Toxicity
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Summary:In this paper we study the calcium uptake in the erythrocyte, a non-excitable cell. This uptake is performed through a passive transport system with two kinetic components (Michaelis-Menten and Hill). The uptake of calcium seems to be driven by voltage through its electrophoretical effect. Lead is capable of inhibiting calcium uptake in a non-competitive manner. As it has been described in other systems, lead is also capable of inhibiting calcium efflux by inhibiting Ca(Mg)-ATPase. Under physiological conditions, the function of ATPase reduces the effect of lead on calcium influx. However, in chronic intoxication a small increment of intracellular calcium is observed, indicating that lead is affecting calcium efflux mainly. We discuss the effects of lead on calcium equilibrium in erythrocytes.
ISSN:0960-3271
1477-0903
DOI:10.1191/096032799678839851