Synthesis and Mössbauer study of 57Fe-based nanoparticles biodegradation in living cells

Biodegradation of nanoparticles includes the destruction of a stabilizing coating and the accompanying change in interparticle interaction, as well as the direct destruction of the inorganic nuclei of particles. These processes lead to characteristic changes in the shape of the Mössbauer spectra of...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2019-05, Vol.474, p.337-342
Main Authors: Yurenya, A., Nikitin, A., Garanina, A., Gabbasov, R., Polikarpov, M., Cherepanov, V., Chuev, M., Majouga, A., Panchenko, V.
Format: Article
Language:English
Subjects:
Aqueous solutions
Biodegradation
Citric acid
Destruction
Iron 57
Iron oxide nanoparticles
Iron oxides
Magnetic nanoparticles
Mossbauer spectroscopy
Nanoparticles
Nanoparticles biodegradation
Oxidation
Relaxation Mossbauer spectroscopy
Spectra
Spectrum analysis
Toxicity
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Summary:Biodegradation of nanoparticles includes the destruction of a stabilizing coating and the accompanying change in interparticle interaction, as well as the direct destruction of the inorganic nuclei of particles. These processes lead to characteristic changes in the shape of the Mössbauer spectra of iron oxide nanoparticles. In this work, we investigated the in vitro biodegradation of 57Fe-based magnetic nanoparticles with the aid of Mössbauer spectroscopy. For this purpose, two types of magnetic nanoparticles enriched with the 57Fe isotope were synthesized. Copolymer Pluronic F-127 and citric acid were used to stabilize nanoparticles in aqueous medium. Moreover, synthesized nanoparticles were analyzed by physicochemical methods and investigated for cytotoxicity. The study of magnetic nanoparticles biodegradation was performed on 4 T1 cell culture (breast cancer). We measured Mössbauer spectra of nanoparticles incubated with 4 T1 cells and spectra of control nanoparticle samples at different conditions. The analysis of spectra was carried out in the many-state relaxation model formalism. The study revealed that after 120-hours incubation of nanoparticles in cells, they did not undergo measurable changes typical of biodegradation processes. Nevertheless, we noted intense intracellular oxidation of ferrous iron of synthesized nanoparticles to the ferric phase. The results obtained indicate the possibility of using the obtained nanoparticles in Mössbauer in vitro studies.
ISSN:0304-8853
1873-4766
DOI:10.1016/j.jmmm.2018.11.040