Viridans streptococcal bacteraemia in patients with neutropenia

Viridans streptococcal bacteraemia is frequent in neutropenic patients. 25 neutropenic patients with viridans streptococcal bacteraemia were compared with 64 control patients. Exposure to repeated chemotherapy or cytarabine were independent risk-factors for streptococcal bacteraemia. The use of carb...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 1995-06, Vol.345 (8965), p.1607-1609
Main Authors: Richard, P., Felice, M-P., Daeschler, T., Richet, H., Amador Del Valle, G., Moreau, P., Milpied, N., Harousseau, J-L.
Format: Article
Language:English
Subjects:
Air flow
Anti-Bacterial Agents - therapeutic use
Antineoplastic Agents - adverse effects
Bacteremia
Bacteremia - etiology
Bacteremia - microbiology
Bacteremia - prevention & control
Bacteria
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Case-Control Studies
Chemotherapy
Cytarabine
Cytarabine - adverse effects
Environment, Controlled
Female
Human bacterial diseases
Humans
Infectious diseases
Leukemia - drug therapy
Lymphoma - drug therapy
Male
Medical research
Medical sciences
Middle Aged
Mouth - microbiology
Mucosa
Neutropenia
Neutropenia - complications
Oral cavity
Patients
Prospective Studies
Risk Factors
Saliva - microbiology
Streptococcal Infections - etiology
Streptococcal Infections - microbiology
Streptococcal Infections - prevention & control
Streptococcus
Streptococcus - isolation & purification
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Viridans streptococcal bacteraemia is frequent in neutropenic patients. 25 neutropenic patients with viridans streptococcal bacteraemia were compared with 64 control patients. Exposure to repeated chemotherapy or cytarabine were independent risk-factors for streptococcal bacteraemia. The use of carboxyureidopenicillins and a stay in laminar-airflow rooms were protective. In a further cohort study of 49 patients, oral streptococci with the same ribotype as blood isolates were recovered from all 7 bacteraemic patients. The oral cavity is a portal of entry for viridans streptococci bacteraemia in neutropenic patients, especially after oral mucosal damage induced by repeated chemotherapy.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(95)90117-5