Secretory carcinoma of the major salivary gland: Provincial population‐based analysis of clinical behavior and outcomes

Background Our aim was to identify the number of cases of secretory carcinoma (SC) of the major salivary gland in a population‐based cohort and review its clinical behavior with long‐term follow‐up. Methods All malignant salivary gland tumors (MSGTs) diagnosed between 1980 and 2014 were assessed for...

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Bibliographic Details
Published in:Head & neck 2019-05, Vol.41 (5), p.1227-1236
Main Authors: Ayre, Gareth, Hyrcza, Martin, Wu, Jonn, Berthelet, Eric, Skálová, Alena, Thomson, Tom
Format: Article
Language:English
Subjects:
Adenocarcinoma
ETV6
Head and neck
head and neck surgery
Lymph nodes
mammary analog secretory carcinoma
MASC
Oral cancer
Salivary gland
salivary gland tumors
Tumors
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Summary:Background Our aim was to identify the number of cases of secretory carcinoma (SC) of the major salivary gland in a population‐based cohort and review its clinical behavior with long‐term follow‐up. Methods All malignant salivary gland tumors (MSGTs) diagnosed between 1980 and 2014 were assessed for histological features compatible with SC and 140 were selected for further analysis. Results Twenty two new cases of SC were identified, 19 of which were originally classified as acinic cell carcinoma, and 3 as adenocarcinoma, not otherwise specified (NOS). Lymph node involvement was less common in SC tumors (5%) than in the control group (11%). Disease recurrence was seen less frequently in SC (9%) than the control group (20%). Mean disease‐free survival was 192 months for SC compared with 162 months for controls (P = 0.15). Conclusion The clinical course of SC is typically indolent with a low risk of relapse not significantly different from other low‐grade MSGT.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25536