Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis

To determine whether clinical outcome in patients with acute alcoholic hepatitis is related to the regenerative capability of the liver, liver biopsy specimens from 25 prospectively recruited patients with acute alcoholic hepatitis were studied for hepatic expression of mRNA for two proliferation ma...

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Bibliographic Details
Published in:The Lancet (British edition) 1994-04, Vol.343 (8901), p.820-823
Main Authors: Fang, J.W.S., Davis, G.L., Lau, J.Y.N., Bird, G.L.A., Nakamura, T.
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Alcoholism
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Biopsy
Cell Division
Epithelium
ErbB Receptors - analysis
Female
Fibrosis
Gene expression
Growth factors
Hepatitis
Hepatitis, Alcoholic - metabolism
Hepatitis, Alcoholic - pathology
Hepatocyte growth factor
Hepatocyte Growth Factor - analysis
Hepatocytes
Histones - analysis
Humans
Immunohistochemistry
Liver
Liver - chemistry
Liver - pathology
Male
Markers
Medical research
Medical sciences
Middle Aged
mRNA
Nuclear Proteins - analysis
Patients
Prognosis
Proliferating Cell Nuclear Antigen
Prospective Studies
Survival
Toxicology
Transforming growth factor
Transforming Growth Factor alpha - analysis
Transforming growth factor-b1
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Summary:To determine whether clinical outcome in patients with acute alcoholic hepatitis is related to the regenerative capability of the liver, liver biopsy specimens from 25 prospectively recruited patients with acute alcoholic hepatitis were studied for hepatic expression of mRNA for two proliferation markers, proliferating cell nuclear antigen and human histone, and for transforming growth factor α (TGFα) and TGFβ1 and hepatocyte growth factor (HGF), which regulate hepatocyte proliferation. Proliferation markers were detected to varying degrees in 0-80% of hepatocytes and occasionally in sinusoidal cells and bile-duct epithelium in 19 patients (76%). Patients who survived for 6 months had greater expression of proliferation markers than those who did not survive (p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(94)92025-7