Effectiveness of filgrastim and polyethylene glycol-filgrastim in the treatment of postchemotherapy neutropenia in children: Phase I clinical trial

Abstract Background: One of the most common side effects of chemotherapy in cancer patients is neutropenia that can result in hospitalization. The purpose of this study was to evaluate the efficacy and tolerability of polyethylene glycol (PEG)-filgrastim compared with filgrastim in the recovery of n...

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Bibliographic Details
Published in:Indian journal of medical and paediatric oncology 2019-01, Vol.40 (1), p.101-104
Main Authors: Yousofian, Saeed, Miri-Aliabad, Ghasem, Kiumarsi, Azadeh, Ramim, Tayeb
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Analysis
Cancer patients
Cancer research
Cancer treatment
Care and treatment
Chemotherapy
Children
Clinical trials
Complications and side effects
Drug dosages
Evidence-based medicine
Glycols (Class of compounds)
Granulocyte colony-stimulating factor
Granulocytes
Health aspects
Infections
Leukemia
Lymphocytic leukemia
Medical research
Neutropenia
Neutrophils
Original Article
Patient compliance
Polyethylene glycol
Polyols
Sargramostim
Studies
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Summary:Abstract Background: One of the most common side effects of chemotherapy in cancer patients is neutropenia that can result in hospitalization. The purpose of this study was to evaluate the efficacy and tolerability of polyethylene glycol (PEG)-filgrastim compared with filgrastim in the recovery of neutropenia. Methods: This study was a Phase I clinical trial conducted among patients with acute lymphoblastic leukemia aged
ISSN:0971-5851
0975-2129
DOI:10.4103/ijmpo.ijmpo_134_18