P21Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis

Human papillomavirus is involved in the carcinogenesis of tonsillar squamous cell carcinomas. Here, we investigated the expression and the prognostic value of key cell cycle proteins in the pRb and p53 pathways in both human papillomavirus type 16-positive and -negative tonsillar squamous cell carci...

Full description

Saved in:
Bibliographic Details
Published in:Modern pathology 2009-05, Vol.22 (5), p.686-698
Main Authors: Hafkamp, Harriët C, Mooren, Jeroen J, Claessen, Sandra MH, Klingenberg, Boris, Voogd, Adri C, Bot, Fredrik J, Klussmann, J Peter, Hopman, Anton HN, Manni, Johannes J, Kremer, Bernd, Ramaekers, Frans CS, Speel, Ernst-Jan M
Format: Article
Language:English
Subjects:
Cancer
Cell cycle
Developmental biology
Human papillomavirus
Laboratory Medicine
Medical prognosis
Medicine
Medicine & Public Health
Oncology
original-article
Otolaryngology
Pathology
Protein expression
Proteins
Regression analysis
Smoking
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human papillomavirus is involved in the carcinogenesis of tonsillar squamous cell carcinomas. Here, we investigated the expression and the prognostic value of key cell cycle proteins in the pRb and p53 pathways in both human papillomavirus type 16-positive and -negative tonsillar squamous cell carcinomas. Using immunohistochemistry, 77 tonsillar squamous cell carcinomas with known human papillomavirus type 16 status and clinical outcome were analyzed for expression of Ki67, p16 INK4A, cyclin D1, pRb, p14 ARF , MDM2, p53, p21 Cip1/WAF1 , and p27 KIP1 . Results were correlated with each other and with clinical and demographic patient data. A total of 35% of tonsillar carcinomas harbored integrated human papillomavirus type 16 DNA and p16 INK4A overexpression, both being considered essential features for human papillomavirus association. These tumors also showed the overexpression of p14 ARF ( P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2009.23