New antifungal agents that inhibit the growth of Candida species : Dichlorinated 8-quinolinols

Five dichlorinated 8-quinolinols (2,5- 5,6-, 3,5-, 3,7-, and 4,5-dichloro-8-quinolinol) were tested against Candida albicans and C. tropicalis in Sabouraud dextrose broth with and without bovine serum. The 5,6-, 3,5-, and 3,7-dichloro-8-quinolinols proved to be more effective than the control, 5-flu...

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Bibliographic Details
Published in:Mycopathologia (1975) 1999, Vol.147 (3), p.117-120
Main Authors: LENTZ, David L, GERSHON, Herman, MARINI, Helen
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacology
Biological and medical sciences
Candida - drug effects
Candida - growth & development
Cell Line
Chloroquinolinols - pharmacology
Cricetinae
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Time Factors
Toxicity Tests
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Summary:Five dichlorinated 8-quinolinols (2,5- 5,6-, 3,5-, 3,7-, and 4,5-dichloro-8-quinolinol) were tested against Candida albicans and C. tropicalis in Sabouraud dextrose broth with and without bovine serum. The 5,6-, 3,5-, and 3,7-dichloro-8-quinolinols proved to be more effective than the control, 5-fluorocytosine. In cytotoxicity tests employing baby hamster kidney (BHK) cells, all test agents proved to be more cytotoxic than the control. However, the minimum inhibitory concentration (MIC) of 3,5-dichloro-8-quinolinol to both fungi was only one tenth the cytotoxic dose, suggesting that the compound may be useful as a topical or systemic antifungal agent.
ISSN:0301-486X
1573-0832
DOI:10.1023/A:1007120913871