Chemical composition and evaluation of antinociceptive activity of the essential oil of Stevia serrata Cav. from Guatemala

The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil was obtained by hydrodistillation of the dried aerial parts of the plant. The essential oil...

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Bibliographic Details
Published in:Natural product research 2019-02, Vol.33 (4), p.577-579
Main Authors: Reis Simas, Daniel Luiz, Mérida-Reyes, Max Samuel, Muñoz-Wug, Manuel Alejandro, Cordeiro, Millena Santos, Giorno, Thais Biondino Sardella, Taracena, Edwin Adolfo, Oliva-Hernández, Bessie Evelyn, Martínez-Arévalo, José Vicente, Fernandes, Patricia Dias, Pérez-Sabino, Juan Francisco, Jorge Ribeiro da Silva, Antonio
Format: Article
Language:English
Subjects:
Analgesics - chemistry
Analgesics - isolation & purification
Analgesics - pharmacology
Animals
Antinocicepive activity
Azulenes - analysis
chamazulene
Chemical composition
essential oil
Essential oils
Formaldehyde
Gas Chromatography-Mass Spectrometry
Guatemala
Mice
Oils & fats
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Oral administration
Organic chemistry
Pain Measurement
Pain perception
sesquiterpenes
Sesquiterpenes - analysis
Sesquiterpenoids
Stevia - chemistry
Stevia serrata
Stevia serrata Cav
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Summary:The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil was obtained by hydrodistillation of the dried aerial parts of the plant. The essential oil analysed by GC-FID and GC-MS showed a high content of sesquiterpenoids, with chamazulene (60.1%) as the major component and 91.5% of the essential oil composition was identified. To evaluate antinociceptive activity in mice, the essential oil of S. serrata Cav. was administered as gavage, using three different doses. In the formalin test, the animals were pre-treated with oral doses of the essential oil before the administration of formalin. Oral administration of S. serrata Cav. essential oil produced a marked antinociceptive activity. Therefore, the plant could be domesticated as a source of essential oil rich in chamazulene for developing medicinal products.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1399376