Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review

Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its wide range of health benefits have been attributed to the modulation of various signalling pathways involved in the development of a particular disease. For example, the antitumour and cancer preventive pr...

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Bibliographic Details
Published in:Natural product research 2019-02, Vol.33 (4), p.527-543
Main Authors: Bommareddy, Ajay, Brozena, Sarah, Steigerwalt, James, Landis, Terra, Hughes, Sarah, Mabry, Erica, Knopp, Aaron, VanWert, Adam L., Dwivedi, Chandradhar
Format: Article
Language:English
Subjects:
Alpha-santalol
Anticancer properties
Apoptosis
Cancer
Cell cycle
Cell death
diabetes
Inflammation
Santalaceae
Signal transduction
Skin
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Summary:Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its wide range of health benefits have been attributed to the modulation of various signalling pathways involved in the development of a particular disease. For example, the antitumour and cancer preventive properties of alpha-santalol have been shown to involve cell death induction through apoptosis and cell cycle arrest in various cancer models. A marked decrease in inflammatory markers have also been shown with alpha-santalol administration in skin tissue models. The current review is aimed at bringing the most recent advances of alpha-santalol against various disease-specific models and highlighting its associated mechanistic details.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1399387