Inhibition of Transient K^sup +^ Current by Copper in Drosophila Neurons

The transient K+ current (IK(A)) affects the rate of repetitive action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM copper to the external saline....

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Bibliographic Details
Published in:Neurochemical research 2004-04, Vol.29 (4), p.785
Main Authors: Alshuaib, Waleed B, Mathew, Mini V
Format: Article
Language:English
Online Access:Get full text
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Summary:The transient K+ current (IK(A)) affects the rate of repetitive action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM copper to the external saline. IK(A) was smaller in the copper-containing saline (12.0 +/- 1.6 pA) than in the control saline (37 +/- 6.5 pA). Activation and inactivation of IK(A) were unchanged by copper. These results suggest that copper can influence neuronal excitability and may affect neuronal function.
ISSN:0364-3190
1573-6903