Frequency of mtDNA A1555G and A7445G mutations among children with prelingual deafness in Turkey

Considerable differences on the frequencies of the mitochondrial 12S rRNA A1555G and tRNA(Ser(UCN)) A7445G mutations have been reported in different populations. Our screening of 168 patients coming from independent Turkish families with prelingual sensorineural non-syndromic deafness revealed three...

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Bibliographic Details
Published in:European journal of pediatrics 2003-03, Vol.162 (3), p.154-158
Main Authors: TEKIN, M, DUMAN, T, BOGOCLU, G, INCESULU, A, COMAK, E, FITOZ, S, YILMAZ, E, IIHAN, I, AKAR, N
Format: Article
Language:English
Subjects:
Adolescent
Aminoglycosides
Anti-Bacterial Agents - adverse effects
Antibiotics
Biological and medical sciences
Cerebral Infarction - complications
Child
Child, Preschool
Deafness
Deafness - chemically induced
Deafness - epidemiology
Deafness - etiology
Deafness - genetics
DNA, Mitochondrial - drug effects
DNA, Mitochondrial - genetics
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Families & family life
Female
Hearing loss
Humans
Male
Medical sciences
Medicine
Mitochondrial DNA
Mutation
Non tumoral diseases
Otorhinolaryngology. Stomatology
Patients
Prevalence
Thrombosis
Tropical medicine
Turkey - epidemiology
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Summary:Considerable differences on the frequencies of the mitochondrial 12S rRNA A1555G and tRNA(Ser(UCN)) A7445G mutations have been reported in different populations. Our screening of 168 patients coming from independent Turkish families with prelingual sensorineural non-syndromic deafness revealed three deaf children with A1555G (1.8%) but no examples of A7445G. One proband with the mitochondrial A1555G mutation has also evidence for right parietal infarct on a brain imaging study, for which common thrombotic mutations were found to be negative. This study shows that the mitochondrial A1555G mutation is among the significant causes of prelingual non-syndromic deafness in the Turkish population.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-002-1129-z