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Cirrhosis in a child with hypothalamic syndrome and central precocious puberty treated with cyproterone acetate

Before the advent of gonadotropin-releasing-hormone analogues, cyproterone acetate (CPA) had been widely prescribed for the treatment of precocious puberty. Although it is usually well tolerated, liver toxicity has been recognized as a complication of its long-term use. We report the occurrence of c...

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Published in:European journal of pediatrics 1999-05, Vol.158 (5), p.367-370
Main Authors: GARTY, B. Z, DINARI, G, GELLVAN, A, KAULI, R
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DINARI, G
GELLVAN, A
KAULI, R
description Before the advent of gonadotropin-releasing-hormone analogues, cyproterone acetate (CPA) had been widely prescribed for the treatment of precocious puberty. Although it is usually well tolerated, liver toxicity has been recognized as a complication of its long-term use. We report the occurrence of cirrhosis in a 10-year-old boy with hypothalamic syndrome and precocious puberty who was treated with CPA for over 50 months. Despite discontinuation of the medication, the liver disease progressed. The patient died of sepsis and multiorgan failure at the age of 14 years. This is the first paediatric report of substantial liver damage and liver toxicity progressing to cirrhosis associated with CPA treatment. Prolonged cyproterone acetate treatment may induce cirrhosis. Monitoring of liver function both during treatment and for several months after discontinuation of therapy is recommended.
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subjects Adolescent
Biological and medical sciences
Chemical and Drug Induced Liver Injury - complications
Chemical and Drug Induced Liver Injury - diagnosis
Chemical and Drug Induced Liver Injury - etiology
Child
Cyproterone Acetate - adverse effects
Cyproterone Acetate - therapeutic use
Drug toxicity and drugs side effects treatment
Fatal Outcome
Humans
Hypothalamic Diseases - complications
Hypothalamic Diseases - diagnosis
Hypothalamic Diseases - drug therapy
Liver Cirrhosis - chemically induced
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
Male
Medical sciences
Multiple Organ Failure - etiology
Pharmacology. Drug treatments
Progesterone Congeners - adverse effects
Progesterone Congeners - therapeutic use
Puberty, Precocious - complications
Puberty, Precocious - diagnosis
Puberty, Precocious - drug therapy
Sepsis - etiology
Syndrome
Toxicity: digestive system
title Cirrhosis in a child with hypothalamic syndrome and central precocious puberty treated with cyproterone acetate
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