Administration of recombinant human granulocyte-colony stimulating factor to septic neonates induces neutrophilia and enhances the neutrophil respiratory burst and ? 2 integrin expression Results of a randomized controlled trial

The objective of this study was to investigate the effect of treatment with recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the neutrophil count and function of preterm neonates with documented sepsis. For this purpose 62 preterm neonates with proven sepsis and 19 healthy preter...

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Bibliographic Details
Published in:European journal of pediatrics 1998-06, Vol.157 (7), p.583-588
Main Authors: Drossou-Agakidou, V., Kanakoudi-Tsakalidou, F., Sarafidis, K., Taparkou, A., Tzimouli, V., Tsandali, H., Kremenopoulos, G.
Format: Article
Language:English
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Summary:The objective of this study was to investigate the effect of treatment with recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the neutrophil count and function of preterm neonates with documented sepsis. For this purpose 62 preterm neonates with proven sepsis and 19 healthy preterm ones were studied. Of the 62 patients, 27 septic neonates had an absolute neutrophil count (ANC) >5000/mm3 (group A) and were scheduled not to receive rhG-CSF and 35/62 had an ANC
ISSN:0340-6199
1432-1076
DOI:10.1007/s004310050884