Integrated Pathways of Candida albicans Revealing Potential Targets and Key Factors Accountable for Pathogenicity

Candida albicans is one of the most opportunistic commensal fungus of human biome found normally in gastrointestinal cavity of healthy humans. Its dimorphic character provides the easy switching of yeast to filamentous form. However, in immunocompromised patients, blood-stream infections often cause...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences, India. Section B: Biological sciences India. Section B: Biological sciences, 2019-06, Vol.89 (2), p.575-584
Main Authors: Mishra, Sonali, Aier, Imlimaong, Varadwaj, Pritish, Misra, Krishna
Format: Article
Language:English
Subjects:
Behavioral Sciences
Biomedical and Life Sciences
Candida
Candida albicans
Drug discovery
Drug resistance
Fungi
Immunocompromised hosts
Life Sciences
Nucleic Acid Chemistry
Pathogenicity
Plant Biochemistry
Research Article
Virulence
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Summary:Candida albicans is one of the most opportunistic commensal fungus of human biome found normally in gastrointestinal cavity of healthy humans. Its dimorphic character provides the easy switching of yeast to filamentous form. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies. Its dimorphic and highly adaptive properties make it even more pathogenic in nature. The hyphal growth causes virulence in Candida . There are many different pathways or factors responsible for the same in Candida albicans . It is thus paramount to see the relationship between the pathways and the key factors of pathogenicity. The common factors can be used to inhibit more than a single pathway at the same time. In the present work, systems biology approach has been employed to summarize all the pathways and common factors leading to yeast to hyphal transition in Candida . The study provides new and potential targets essential for antifungal drug discovery which is highly required against drug resistance.
ISSN:0369-8211
2250-1746
DOI:10.1007/s40011-018-0964-2