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Operation Everest III: role of plasma volume expansion on VO2max during prolonged high-altitude exposure
1 Ecole Nationale de Ski et d'alpinisme, 74401 Chamonix; 2 Association pour la Recherche en Physiologie de l'Environnement, 93017 Bobigny; 3 Laboratoire de Physiologie, hôpital Necker, 75015 Paris; 4 Laboratoire de Biochimie, hôpital Jean Verdier, 93140 Bondy; and 5 COMEX S.A., 13275 ...
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| Published in: | Journal of applied physiology (1985) 2000-07, Vol.89 (1), p.29-37 |
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| container_title | Journal of applied physiology (1985) |
| container_volume | 89 |
| creator | Robach, Paul Dechaux, Michele Jarrot, Sebastien Vaysse, Jenny Schneider, Jean-Christophe Mason, Nicholas P Herry, Jean-Pierre Gardette, Bernard Richalet, Jean-Paul |
| description | 1 Ecole Nationale de Ski et d'alpinisme, 74401 Chamonix;
2 Association pour la Recherche en Physiologie de
l'Environnement, 93017 Bobigny; 3 Laboratoire de Physiologie,
hôpital Necker, 75015 Paris; 4 Laboratoire de Biochimie,
hôpital Jean Verdier, 93140 Bondy; and 5 COMEX S.A., 13275 Marseille, France
We hypothesize that plasma volume
decrease ( PV) induced by high-altitude (HA) exposure and intense
exercise is involved in the limitation of maximal O 2 uptake
( O 2 max ) at HA. Eight male subjects were decompressed for 31 days in a hypobaric chamber to the
barometric equivalent of Mt. Everest (8,848 m). Maximal exercise was
performed with and without plasma volume expansion (PVX, 219-292
ml) during exercise, at sea level (SL), at HA (370 mmHg, equivalent to
6,000 m after 10-12 days) and after return to SL (RSL, 1-3
days). Plasma volume (PV) was determined at rest at SL, HA, and RSL by
Evans blue dilution. PV was decreased by 26% ( P |
| format | article |
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2 Association pour la Recherche en Physiologie de
l'Environnement, 93017 Bobigny; 3 Laboratoire de Physiologie,
hôpital Necker, 75015 Paris; 4 Laboratoire de Biochimie,
hôpital Jean Verdier, 93140 Bondy; and 5 COMEX S.A., 13275 Marseille, France
We hypothesize that plasma volume
decrease ( PV) induced by high-altitude (HA) exposure and intense
exercise is involved in the limitation of maximal O 2 uptake
( O 2 max ) at HA. Eight male subjects were decompressed for 31 days in a hypobaric chamber to the
barometric equivalent of Mt. Everest (8,848 m). Maximal exercise was
performed with and without plasma volume expansion (PVX, 219-292
ml) during exercise, at sea level (SL), at HA (370 mmHg, equivalent to
6,000 m after 10-12 days) and after return to SL (RSL, 1-3
days). Plasma volume (PV) was determined at rest at SL, HA, and RSL by
Evans blue dilution. PV was decreased by 26% ( P < 0.01) at HA and was 10% higher at RSL than at SL. Exercise-induced PV was reduced both by PVX and HA ( P < 0.05).
Compared with SL, O 2 max was
decreased by 58 and 11% at HA and RSL, respectively. O 2 max was enhanced by PVX at
HA (+9%, P < 0.05) but not at SL or RSL. The more PV
was decreased at HA, the more
O 2 max was improved by PVX
( P < 0.05). At exhaustion, plasma renin and
aldosterone were not modified at HA compared with SL but were higher at
RSL, whereas plasma atrial natriuretic factor was lower at HA. The present results suggest that PV contributes to the limitation of
O 2 max during acclimatization
to HA. RSL-induced PVX, which may be due to increased activity of the
renin-aldosterone system, could also influence the recovery of
O 2 max .
hypoxia; blood volume; plasma lactate; gas exchange</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>PMID: 10904032</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Altitude ; Applied physiology ; Biological and medical sciences ; Blood ; Human physiology applied to population studies and life conditions. Human ecophysiology ; Medical sciences ; Oxygen ; Plasma ; Transports. Aerospace. Diving. Altitude</subject><ispartof>Journal of applied physiology (1985), 2000-07, Vol.89 (1), p.29-37</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society Jul 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1467227$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Robach, Paul</creatorcontrib><creatorcontrib>Dechaux, Michele</creatorcontrib><creatorcontrib>Jarrot, Sebastien</creatorcontrib><creatorcontrib>Vaysse, Jenny</creatorcontrib><creatorcontrib>Schneider, Jean-Christophe</creatorcontrib><creatorcontrib>Mason, Nicholas P</creatorcontrib><creatorcontrib>Herry, Jean-Pierre</creatorcontrib><creatorcontrib>Gardette, Bernard</creatorcontrib><creatorcontrib>Richalet, Jean-Paul</creatorcontrib><title>Operation Everest III: role of plasma volume expansion on VO2max during prolonged high-altitude exposure</title><title>Journal of applied physiology (1985)</title><description>1 Ecole Nationale de Ski et d'alpinisme, 74401 Chamonix;
2 Association pour la Recherche en Physiologie de
l'Environnement, 93017 Bobigny; 3 Laboratoire de Physiologie,
hôpital Necker, 75015 Paris; 4 Laboratoire de Biochimie,
hôpital Jean Verdier, 93140 Bondy; and 5 COMEX S.A., 13275 Marseille, France
We hypothesize that plasma volume
decrease ( PV) induced by high-altitude (HA) exposure and intense
exercise is involved in the limitation of maximal O 2 uptake
( O 2 max ) at HA. Eight male subjects were decompressed for 31 days in a hypobaric chamber to the
barometric equivalent of Mt. Everest (8,848 m). Maximal exercise was
performed with and without plasma volume expansion (PVX, 219-292
ml) during exercise, at sea level (SL), at HA (370 mmHg, equivalent to
6,000 m after 10-12 days) and after return to SL (RSL, 1-3
days). Plasma volume (PV) was determined at rest at SL, HA, and RSL by
Evans blue dilution. PV was decreased by 26% ( P < 0.01) at HA and was 10% higher at RSL than at SL. Exercise-induced PV was reduced both by PVX and HA ( P < 0.05).
Compared with SL, O 2 max was
decreased by 58 and 11% at HA and RSL, respectively. O 2 max was enhanced by PVX at
HA (+9%, P < 0.05) but not at SL or RSL. The more PV
was decreased at HA, the more
O 2 max was improved by PVX
( P < 0.05). At exhaustion, plasma renin and
aldosterone were not modified at HA compared with SL but were higher at
RSL, whereas plasma atrial natriuretic factor was lower at HA. The present results suggest that PV contributes to the limitation of
O 2 max during acclimatization
to HA. RSL-induced PVX, which may be due to increased activity of the
renin-aldosterone system, could also influence the recovery of
O 2 max .
hypoxia; blood volume; plasma lactate; gas exchange</description><subject>Altitude</subject><subject>Applied physiology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Human physiology applied to population studies and life conditions. Human ecophysiology</subject><subject>Medical sciences</subject><subject>Oxygen</subject><subject>Plasma</subject><subject>Transports. Aerospace. Diving. Altitude</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1j01Lw0AQhoMotlb_wyLiLbBfyWa9SalaKPRSvS7bZPJRNsm6m9T237u1vQoDc3med-a9iqYkoTQmKSbX0TQTCY5FkolJdOf9DmPCeUJuownBEnPM6DSq1xacHpq-Q4s9OPADWi6XL8j1BlBfImu0bzXa92ZsAcHB6s6f4DBfa9rqAypG13QVssHouwoKVDdVHWszNMNY_Cm9Hx3cRzelNh4eLnsWfb4tNvOPeLV-X85fV3FNGBZxCmkutJSZTraaYyq2VGQMZwBcApNUM85AcpGlOUtTwUiSgyyxFFIkOROYzaLHc2546HsMfdSuH10XTipKKZESMxGgpwukfa5N6XSXN15Z17TaHRXhqaD0hNEzdqr00zhQtj6G-qavjuptNGYDh5CvbSYVUVQqW5RBev5fCqy6wOwX0ouB6w</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Robach, Paul</creator><creator>Dechaux, Michele</creator><creator>Jarrot, Sebastien</creator><creator>Vaysse, Jenny</creator><creator>Schneider, Jean-Christophe</creator><creator>Mason, Nicholas P</creator><creator>Herry, Jean-Pierre</creator><creator>Gardette, Bernard</creator><creator>Richalet, Jean-Paul</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20000701</creationdate><title>Operation Everest III: role of plasma volume expansion on VO2max during prolonged high-altitude exposure</title><author>Robach, Paul ; Dechaux, Michele ; Jarrot, Sebastien ; Vaysse, Jenny ; Schneider, Jean-Christophe ; Mason, Nicholas P ; Herry, Jean-Pierre ; Gardette, Bernard ; Richalet, Jean-Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1307-6e6c7a998a5ba4027b278308ee49e392a343e94786c3667315ce9f097975c3703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Altitude</topic><topic>Applied physiology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Human physiology applied to population studies and life conditions. Human ecophysiology</topic><topic>Medical sciences</topic><topic>Oxygen</topic><topic>Plasma</topic><topic>Transports. Aerospace. Diving. Altitude</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robach, Paul</creatorcontrib><creatorcontrib>Dechaux, Michele</creatorcontrib><creatorcontrib>Jarrot, Sebastien</creatorcontrib><creatorcontrib>Vaysse, Jenny</creatorcontrib><creatorcontrib>Schneider, Jean-Christophe</creatorcontrib><creatorcontrib>Mason, Nicholas P</creatorcontrib><creatorcontrib>Herry, Jean-Pierre</creatorcontrib><creatorcontrib>Gardette, Bernard</creatorcontrib><creatorcontrib>Richalet, Jean-Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robach, Paul</au><au>Dechaux, Michele</au><au>Jarrot, Sebastien</au><au>Vaysse, Jenny</au><au>Schneider, Jean-Christophe</au><au>Mason, Nicholas P</au><au>Herry, Jean-Pierre</au><au>Gardette, Bernard</au><au>Richalet, Jean-Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Operation Everest III: role of plasma volume expansion on VO2max during prolonged high-altitude exposure</atitle><jtitle>Journal of applied physiology (1985)</jtitle><date>2000-07-01</date><risdate>2000</risdate><volume>89</volume><issue>1</issue><spage>29</spage><epage>37</epage><pages>29-37</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Ecole Nationale de Ski et d'alpinisme, 74401 Chamonix;
2 Association pour la Recherche en Physiologie de
l'Environnement, 93017 Bobigny; 3 Laboratoire de Physiologie,
hôpital Necker, 75015 Paris; 4 Laboratoire de Biochimie,
hôpital Jean Verdier, 93140 Bondy; and 5 COMEX S.A., 13275 Marseille, France
We hypothesize that plasma volume
decrease ( PV) induced by high-altitude (HA) exposure and intense
exercise is involved in the limitation of maximal O 2 uptake
( O 2 max ) at HA. Eight male subjects were decompressed for 31 days in a hypobaric chamber to the
barometric equivalent of Mt. Everest (8,848 m). Maximal exercise was
performed with and without plasma volume expansion (PVX, 219-292
ml) during exercise, at sea level (SL), at HA (370 mmHg, equivalent to
6,000 m after 10-12 days) and after return to SL (RSL, 1-3
days). Plasma volume (PV) was determined at rest at SL, HA, and RSL by
Evans blue dilution. PV was decreased by 26% ( P < 0.01) at HA and was 10% higher at RSL than at SL. Exercise-induced PV was reduced both by PVX and HA ( P < 0.05).
Compared with SL, O 2 max was
decreased by 58 and 11% at HA and RSL, respectively. O 2 max was enhanced by PVX at
HA (+9%, P < 0.05) but not at SL or RSL. The more PV
was decreased at HA, the more
O 2 max was improved by PVX
( P < 0.05). At exhaustion, plasma renin and
aldosterone were not modified at HA compared with SL but were higher at
RSL, whereas plasma atrial natriuretic factor was lower at HA. The present results suggest that PV contributes to the limitation of
O 2 max during acclimatization
to HA. RSL-induced PVX, which may be due to increased activity of the
renin-aldosterone system, could also influence the recovery of
O 2 max .
hypoxia; blood volume; plasma lactate; gas exchange</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10904032</pmid><tpages>9</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2000-07, Vol.89 (1), p.29-37 |
| issn | 8750-7587 1522-1601 |
| language | eng |
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| source | American Physiological Society Journals; American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list) |
| subjects | Altitude Applied physiology Biological and medical sciences Blood Human physiology applied to population studies and life conditions. Human ecophysiology Medical sciences Oxygen Plasma Transports. Aerospace. Diving. Altitude |
| title | Operation Everest III: role of plasma volume expansion on VO2max during prolonged high-altitude exposure |
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