Decreased airway narrowing and smooth muscle contraction in hyperresponsive pigs

Department of Physiology, University of Western Australia, Perth, Western Australia 6009, Australia Increased smooth muscle contractility or reduced smooth muscle mechanical loads could account for the excessive airway narrowing and hyperresponsiveness seen in asthma. These mechanisms were investiga...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied physiology (1985) 2002-10, Vol.93 (4), p.1296-1300
Main Authors: Turner, Debra J, Noble, Peter B, Lucas, Matthew P, Mitchell, Howard W
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Air breathing
Animals
Asthma
Biological and medical sciences
Bronchial Hyperreactivity - physiopathology
Bronchoconstriction
Electric Stimulation
Female
Fundamental and applied biological sciences. Psychology
Hogs
In Vitro Techniques
Isometric Contraction
Muscle Contraction
Muscle, Smooth - drug effects
Muscle, Smooth - physiopathology
Muscular system
Respiratory system
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Swine
Trachea - drug effects
Trachea - physiopathology
Vertebrates: respiratory system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Department of Physiology, University of Western Australia, Perth, Western Australia 6009, Australia Increased smooth muscle contractility or reduced smooth muscle mechanical loads could account for the excessive airway narrowing and hyperresponsiveness seen in asthma. These mechanisms were investigated by using an allergen-induced porcine model of airway hyperresponsiveness. Airway narrowing to electric field stimulation was measured in isolated bronchial segments, over a range of transmural pressures (0-20 cmH 2 O). Contractile responses to ACh were measured in bronchial segments and in isolated tracheal smooth muscle strips isolated from control and test (ovalbumin sensitized and challenged) pigs. Test airways narrowed less than controls ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00150.2002