Forearm muscle metabolism studied using 31P-MRS during prograssive exercise to fatigue after Acz administration

The effects of acetazolamide-induced carbonic anhydrase inhibition (CAI) on muscle intracellular thresholds for intracellular pH and inorganic phosphate-to-phosphate creatine ratio and the plasma lactate (La-) threshold were examined. The data suggest that the lower plasma lactate concentration seen...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2000-07, Vol.89 (1), p.200
Main Authors: Kowalchuk, John M, Smith, Shelly A, Weening, Brad S, Marsh, Greg D, Paterson, Donald H
Format: Article
Language:English
Subjects:
Cells
Exercise
Metabolism
Muscular system
Phosphates
Plasma
Online Access:Get full text
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Summary:The effects of acetazolamide-induced carbonic anhydrase inhibition (CAI) on muscle intracellular thresholds for intracellular pH and inorganic phosphate-to-phosphate creatine ratio and the plasma lactate (La-) threshold were examined. The data suggest that the lower plasma lactate concentration seen with CAI was not due to a delayed onset of rate of muscle La- accumulation but may be related to impaired La- removal from muscle.
ISSN:8750-7587
1522-1601