Modeling of a Developing Planar Network of Cortical Neurons for Studying the Effects of Pharmacologically Modified Synaptic Connectivity on Cell Rhythmogenesis

A software tool for studying neural networks grown on planar substrates is described. The tool provides: (i) modeling the neuritic fields of individual neurons and their dynamic connectivity, (ii) creation of templates, "cloning" and connecting multiple instances of the neurons, (iii) comp...

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Bibliographic Details
Published in:Neurophysiology (New York) 2002-03, Vol.34 (2-3), p.219
Main Authors: Samarin, A V, Igarashi, Y, Korogod, S M
Format: Article
Language:English
Online Access:Get full text
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Summary:A software tool for studying neural networks grown on planar substrates is described. The tool provides: (i) modeling the neuritic fields of individual neurons and their dynamic connectivity, (ii) creation of templates, "cloning" and connecting multiple instances of the neurons, (iii) computing the cellular electrical activity and Ca2+ dynamics, and (iv) estimating synchronization of the networked cells. Examples are shown of employing this tool for the study of synchronization of burst discharges in a network of the cortical neurons, whose connectivity is modified by neuropsin.
ISSN:0090-2977
1573-9007
DOI:10.1023/A:1020775905501