Changes in the NCAM Level in the Brain Structures of Stressed Rats and Recovery of This Level by Haloperidol Treatment

Rats were subjected to a fractionated stress procedure (randomized application of repeated and combined acoustic, light-flash, and nociceptive stimulations, 1 h daily over 1 month). After this session, the NCAM levels in the striatum, mesencephalon, and neocortex increased by 57-74%. Single injectio...

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Bibliographic Details
Published in:Neurophysiology (New York) 2000-09, Vol.32 (5), p.321
Main Authors: Ushakova, G A, Berezin, V A, Nerush, P A
Format: Article
Language:English
Online Access:Get full text
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Summary:Rats were subjected to a fractionated stress procedure (randomized application of repeated and combined acoustic, light-flash, and nociceptive stimulations, 1 h daily over 1 month). After this session, the NCAM levels in the striatum, mesencephalon, and neocortex increased by 57-74%. Single injections of 1.5 mg/kg haloperidol 40 min to 24 h before sacrificing decreased the NCAM levels in all the above structures practically to control values. Injections of an anticonvulsant, sodium valproate (200 mg/kg), did not change the NCAM levels increased after stressing. We conclude that under stress conditions NCAM are involved in plastic transformations of the synaptic structures, mostly in populations of the excitatory neurons. This is not accompanied by qualitative modifications in the NCAM form composition.
ISSN:0090-2977
1573-9007
DOI:10.1023/A:1010371322632