Reduction of delayed renal allograft function using sequential immunosuppression

Previous data suggested that outcome in small children with cadaveric renal transplantation might be improved with sequential therapy. This protocol combines augmented immunosuppression [by including antibody induction (ATG)] with avoidance of nephrotoxic medication in the immediate postoperative ph...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2001-08, Vol.16 (8), p.613-617
Main Authors: MÜLLER, Thomas, RUFFINGSHOFER, Dagmar, BIDMON, Bettina, ARBEITER, Klaus, BALZAR, Egon, AUFRICHT, Christoph
Format: Article
Language:English
Subjects:
Antibodies
Antibodies - therapeutic use
Azathioprine - administration & dosage
Azathioprine - therapeutic use
Biological and medical sciences
Child, Preschool
Creatinine
Cyclosporine - adverse effects
Cyclosporine - therapeutic use
Drug Therapy, Combination
Female
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Graft Rejection - epidemiology
Graft Survival
Humans
Hypertension - epidemiology
Immunosuppression - methods
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - therapeutic use
Incidence
Infant
Infection - epidemiology
Kidney - physiopathology
Kidney Transplantation - immunology
Kidney transplants
Male
Medical sciences
Patients
Pediatrics
Peritoneal dialysis
Postoperative Complications - epidemiology
Prednisone - administration & dosage
Prednisone - therapeutic use
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
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Summary:Previous data suggested that outcome in small children with cadaveric renal transplantation might be improved with sequential therapy. This protocol combines augmented immunosuppression [by including antibody induction (ATG)] with avoidance of nephrotoxic medication in the immediate postoperative phase (by delayed start of cyclosporin therapy). In this report, we describe effects of this approach in 12 consecutively transplanted small children of less than 5 years of age (mean 3.2 years) who received a cadaveric renal graft at our institution between 1991 and 1998. Up to 1996 triple therapy (prednisolone, azathioprine, cyclosporin) and since 1997 sequential therapy (prednisolone, azathioprine, ATG until serum creatinine
ISSN:0931-041X
1432-198X
DOI:10.1007/s004670100616