Acute tubulointerstitial nephritis following ingestion of Chlorella tablets

Here, we report on a boy with acute tubulointerstitial nephritis (ATIN), who developed it following ingestion of Chlorella tablets as a food supplement. He was incidentally detected to have glucosuria, proteinuria, and leukocyturia during school mass screening. He had had a history of ingestion of C...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2007-06, Vol.22 (6), p.887-888
Main Authors: Yim, Hyung Eun, Yoo, Kee Hwan, Seo, Won Hee, Won, Nam Hee, Hong, Young Sook, Lee, Joo Won
Format: Article
Language:English
Subjects:
Acute Disease
Care and treatment
Child
Chlorella
Chlorella - chemistry
Complications and side effects
Development and progression
Dietary Supplements - adverse effects
Glucocorticoids - therapeutic use
Humans
Male
Nephritis
Nephritis, Interstitial - chemically induced
Nephritis, Interstitial - pathology
Nephritis, Interstitial - physiopathology
Patient outcomes
Plant Extracts - adverse effects
Poisoning - drug therapy
Poisoning - etiology
Poisoning - pathology
Prednisolone - therapeutic use
Risk factors
Treatment Outcome
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Summary:Here, we report on a boy with acute tubulointerstitial nephritis (ATIN), who developed it following ingestion of Chlorella tablets as a food supplement. He was incidentally detected to have glucosuria, proteinuria, and leukocyturia during school mass screening. He had had a history of ingestion of Chlorella tablets for 3 months. Laboratory studies showed anemia, increased levels of creatinine, decreased glomerular filtration rate (GFR), hypokalemia, hypo-uricemia, hypophosphatemia, hypergammaglobulinemia, proteinuria, leukocyturia, and glucosuria. ATIN was diagnosed by renal biopsy. The patient's renal function improved after initiation of corticosteroid therapy and discontinuation of Chlorella for 6 months. Chlorella may be a causative allergen inducing tubulointerstitial injury in kidney.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-006-0420-z