Orthogonally Photocontrolled Non‐Autonomous DNA Walker

There is considerable interest in developing progressively moving devices on the nanoscale, with the aim of using them as parts of programmable therapeutics, smart materials, and nanofactories. Present here is an entirely light‐induced DNA walker based on orthogonal photocontrol. Implementing two az...

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Bibliographic Details
Published in:Angewandte Chemie 2019-05, Vol.131 (21), p.7022-7025
Main Authors: Škugor, Marko, Valero, Julián, Murayama, Keiji, Centola, Mathias, Asanuma, Hiroyuki, Famulok, Michael
Format: Article
Language:English
Subjects:
Azo compounds
Azoverbindungen
Chemistry
Deoxyribonucleic acid
DNA
Fluoreszenz
Irradiation
Molecular motors
Nanostrukturen
Photochemie
Radiation
Smart materials
Wavelengths
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Summary:There is considerable interest in developing progressively moving devices on the nanoscale, with the aim of using them as parts of programmable therapeutics, smart materials, and nanofactories. Present here is an entirely light‐induced DNA walker based on orthogonal photocontrol. Implementing two azobenzene derivatives, S‐DM‐Azo and DM‐Azo, enabled precise coordination of strand displacement reactions that powered a biped walker and guided it along a defined track in a non‐autonomous way. This unprecedented type of molecular walker design offers high precision control over the movement in back‐and‐forth directions as desired, and is regulated solely by the sequence of the irradiation wavelengths. This concept may open new avenues for advancing non‐autonomous progressive molecular motors, ultimately facilitating their application at the nanoscale. Ein nicht‐autonomer DNA‐Walker kann auf einem definierten Pfad zwei Schritte vor und zurück ausführen und wird ausschließlich durch orthogonale Lichteinstrahlung angetrieben. Bestrahlung mit unterschiedlichen Wellenlängen in einer definierten Reihenfolge führt zu einer präzisen Steuerung der Bewegung und Position des Walkers bei jedem Schritt. Die nicht‐invasive Regulation mehrstufiger prozessiver Bewegung ist die erste kritische Errungenschaft auf dem Weg zu einer Nanorobotik.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201901272