Membranous lupus nephritis in Chinese children—a case series and review of the literature

We retrospectively reviewed the cases of 13 lupus nephritis children with pure membranous glomerulonephritis (MGN; Group A) and ten children with mixed proliferative and membranous nephritis (Group B). The children were identified through a territory-wide survey of patients between 1990 and 2003. Al...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2009-10, Vol.24 (10), p.1989-1996
Main Authors: Wong, Sik-Nin, Chan, Winnie Kwai-Yu, Hui, Joannie, Chim, Stella, Lee, Tsz-Leung, Lee, Kwok-Piu, Leung, Lettie Chuk-Kwan, Tse, Niko Kei-Chiu, Yuen, So-Fun
Format: Article
Language:English
Subjects:
Adolescent
Anti-Inflammatory Agents - therapeutic use
Asian Continental Ancestry Group
Azathioprine - therapeutic use
Biopsy
Care and treatment
Child
Child, Preschool
Children
Complications and side effects
Creatinine
Cyclophosphamide - therapeutic use
Cyclosporins - therapeutic use
Cytotoxicity
Diagnosis
Diseases
Drug Therapy, Combination
Edema
Female
Glomerular Filtration Rate
Hematuria
Humans
Hypertension
Immunosuppressive Agents - therapeutic use
Literature reviews
Lupus
Lupus Nephritis - drug therapy
Lupus Nephritis - physiopathology
Male
Medical prognosis
Medicine
Medicine & Public Health
Microscopy
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Nephritis
Nephrology
Original Article
Patient outcomes
Patients
Pediatrics
Prednisolone - therapeutic use
Retrospective Studies
Risk factors
Treatment Outcome
Urine
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We retrospectively reviewed the cases of 13 lupus nephritis children with pure membranous glomerulonephritis (MGN; Group A) and ten children with mixed proliferative and membranous nephritis (Group B). The children were identified through a territory-wide survey of patients between 1990 and 2003. All were ethnic Chinese. Age at diagnosis ranged from 3.7 to 18.6 years (Group A) and from 9.6 to 22.1 years (Group B). Female-to-male ratios were 12:1 (Group A) and 9:1 (Group B). Group A patients were more often nephrotic than Group B patients (11/13 vs. 5/10, p  = 0.17). The glomerular filtration rate (GFR) at presentation was normal in all but two patients (one from each group). For induction, Group B patients consistently received prednisolone and cyclophosphamide; in contrast, the cytotoxic regimens in Group A patients varied from cyclophosphamide (five patients), mycophenolate mofetil (two patients), azathiorpine plus cyclosporine (one patient), and azathioprine alone (one patient). After a median follow-up of 7.6–7.8 years, one Group A patient had died of fulminant lupus. One survivor in Group B had a GFR 
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-009-1257-z