Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride‐induced hepatotoxicity in rats

It has been proposed carbon tetrachloride (CCl4) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant act...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-07, Vol.120 (7), p.11853-11858
Main Authors: Yousefi‐Manesh, Hasan, Shirooie, Samira, Partoazar, Alireza, Nikoui, Vahid, Estakhri, Mohammad Reza Abdollahzadeh, Bakhtiarian, Azam
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
antioxidant
Antioxidants
Aspartate aminotransferase
Carbon
Carbon tetrachloride
Catalase
CCl4
Free radicals
hepatoprotective
Hepatotoxicity
Intoxication
Lecithin
Levels
liposome
Liposomes
Malondialdehyde
Phosphatidylcholine
Phosphatidylserine
Reactive oxygen species
Rodents
Serum levels
Superoxide dismutase
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Summary:It has been proposed carbon tetrachloride (CCl4) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous studies. Therefore, this study was aimed to investigate the effects of PS liposomes treatment against the CCl4‐induced hepatotoxicity in a rat model. Male Wistar rats were treated with PS (10 mg/kg, oral) or phosphatidylcholine liposomes (PC) (10 mg/kg, oral) for 3 days before CCl4 (2 ml/kg; ip once on the third day) injection. The serum level of ALT, AST, and ALP were measured. Also, antioxidant assays were performed. Administration of PS with CCl4 significantly inhibited alterations in the serum levels of AST, ALP (**P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.28464