Flurbiprofen, S(+), eyedrops: formulation, enantiomeric assay, shelflife and pharmacology

Aphakic cystoid macula edema, occurring after cataract extraction is ascribed to trauma-induced production of intra-ocular prostaglandins. Sufficient experimental and clinical evidence supports the use of prostaglandin synthesis inhibitors to countervail this clinical condition. The active S(+)-enan...

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Bibliographic Details
Published in:Pharmacy world and science 1999-04, Vol.21 (2), p.91
Main Authors: van Sorge, Adriaan A, Wijnen, Peter H, van Delft, Jan L, Valerie M.W. Carballosa Core-Bodelier, van Haeringen, Nicolaas J
Format: Article
Language:English
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Summary:Aphakic cystoid macula edema, occurring after cataract extraction is ascribed to trauma-induced production of intra-ocular prostaglandins. Sufficient experimental and clinical evidence supports the use of prostaglandin synthesis inhibitors to countervail this clinical condition. The active S(+)-enantiomer of flurbiprofen, a prostaglandin synthesis inhibitor, has been formulated into a stereoselective, ballast free eyedrop solution in a concentration of 0.015%. Analysis by capillary zone electrophoresis shows shelf-life stability up to four years at room temperature of this enantiomer. The inhibitory effect on the synthesis of prostaglandins as measured on a homogenate bovine iris/ciliary body, remained unaffected during a shelf-life period of three years.
ISSN:2210-7703
2210-7711
DOI:10.1023/A:1008609513880