Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivity, Cardiovascular Disease, and Drug Metabolism

This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investiga...

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Bibliographic Details
Published in:Annual review of medicine 2003-02, Vol.54 (1), p.371-392
Main Authors: Costa, Lucio G, Cole, Toby B, Jarvik, Gail P, Furlong, Clement E
Format: Article
Language:English
Subjects:
Cardiovascular disease
drug metabolism
Enzymes
Genomics
Hypotheses
Insecticides
linkage disequilibrium
Metabolism
metabolism of oxidized lipids
nerve agents
organophosphate metabolism
statin metabolism
Toxicity
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Summary:This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.54.101601.152421